A gold color metal and enamel insignia 1 3/16 inches (3.02 cm) in height overall consisting of a white keystone surmounted by a scarlet Greek cross bearing in the center a gold locomotive wheel, all between a semicircular maroon scroll, folded back on each side, passing under the horizontal arms of the cross, and bearing at the top the inscription "SOUND BODY" and in base "SHARP MIND" all in gold letters.
The Greek cross is a symbol of aid and assistance. The keystone represents the location of the unit's headquarters in Pennsylvania. The locomotive wheel refers historically to the unit's service in England and France during World War II as the 59th Hospital Train. Maroon and white are colors used for the Army Medical Department.
The distinctive unit insignia was originally approved for the 338th Medical Group on 29 November 1972. It was redesignated effective 17 September 2002, with description and symbolism updated for the 338th Medical Brigade.